There has been well over 50 major league players who have played in the series since it's inception.  Among those are Kevin Bass (Astros), Buddy Biancalana (Astros/Royals), Al Davis (Mariners), Eric Plunk (A's), Randy Johnson (Mariners/Astros), Mike Moore (A's), Phil Stephenson (Cubs), Mickey Tettleton (A's/Orioles), John Russell (Phillies), and Johnny Damon (Royals).  Additionally, Troy Aikman of the Dallas Cowboys was a series participant.

Arizona Sun Belt Players who have played in the Major Legues include:
Andy Pratt (Atlanta Braves, Chicago Cubs), Brian Anderson (Chicago White Sox), Chris Duncan (St. Louis Cardinals), JD Durbin (Minnesota Twins), Brian Bannister (New York Mets), Andre Either (Los Angeles Dodgers), J.J. Hardy (Milwaukee Brewers), Brandon Wood (Los Angeles Angels of Anthiem), Elliot Johnson (Tampa Bay Rays), Doug Mathis (Texas Rangers), Donnie Veal (Pittsburgh Pirates), Tim Woods (Florida Marlins), Ike Davis (New York Mets), Matt Pagnozzi (St. Louis Cardinals) and Eric Sogard (Oakland A's).